Modularity, Integration and IT Personnel Skills Factors in Linking ERP to SCM Systems

This study investigates some underlying technological factors for linking enterprise resource planning (ERP) to supply chain management (SCM) systems. ERP systems serve technological requirements across functional areas within a corporate boundary while SCM systems focus on collaborative relationships with partners in the supply chain, emphasizing business process integration and information sharing through IT. In order to facilitate SCM operations for business planning and decision making, an ERP system must be extensible in terms of support for a range of external constituents in the supply chain. The research reported in this paper investigates these linkages and provides a framework for developing and evaluating SCM processes in order to serve enterprise needs in terms of resource management for scalability, implementation costs and operational efficiency for meeting the business objectives

Operations research models and methods for safety stock determination: A review

In supply chain inventory management it is generally accepted that safety stocks are a suitable strategy to deal with demand and supply uncertainty aiming to prevent inventory stock-outs. Safety stocks have been the subject of intensive research, typically covering the problems of dimensioning, positioning, managing and placement. Here, we narrow the scope of the discussion to the safety stock dimensioning problem, consisting in determining the proper safety stock level for each product. This paper reports the results of a recent in-depth systematic literature review (SLR) of operations research (OR) models and methods for dimensioning safety stocks. To the best of our knowledge, this is the first systematic review of the application of OR-based approaches to investigate this problem. A set of 95 papers published from 1977 to 2019 has been reviewed to identify the type of model being employed, as well as the modeling techniques and main performance criteria used. At the end, we highlight current literature gaps and discuss potential research directions and trends that may help to guide researchers and practitioners interested in the development of new OR-based approaches for safety stock determination.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020, and by the European Structural and Investment Funds in the FEDER component, through the Operational Competitiveness and Internationalization Program (COMPETE 2020) [Project no. 39479, Funding reference: POCI-01-0247-FEDER-39479]

Six-membered ring systems: with O and/or S atoms

A large variety of publications have emerged in 2012 involving O- and S-6- membered ring systems. The increasing number of reviews and other communica- tions dedicated to natural and synthetic derivatives and their biological significance highlights the importance of these heterocycles. Reviews on natural products involve biosynthesis and isolation of enantiomeric derivatives h12AGE4802i, biosynthesis, isolation, synthesis, and biological studies on the pederin family h12NPR980i and xanthones obtained from fungi, lichens, and bacteria h12CR3717i and on the potential chemotherapeutic value of phyto- chemical products and plant extracts as antidiabetic h12NPR580i, antimicrobial, and resistance-modifying agents h12NPR1007i. A more specific review covers a structure–activity relationship of endoperoxides from marine origin and their antitry- panosomal activity h12OBC7197i. New synthetic routes to naturally occurring, biologically active pyran derivatives have been the object of several papers. Different approaches have been discussed for the total synthesis of tetrahydropyran-containing natural products (")-zampanolide h12CEJ16868, 12EJO4130, 12OL3408i, (")-aspergillides A and B h12H(85)587, 12H(85)1255, 12TA252i, (þ)-neopeltolide h12JOC2225, 12JOC9840, 12H(85) 1255i, or their macrolactone core h12OBC3689, 12OL2346i. The total synthesis of bistramide A h12CEJ7452i and (þ)-kalihinol A h12CC901i and the stereoselec- tive synthesis of a fragment of bryostatin h12S3077, 12TL6163i have also been sur- veyed. Other papers relate the total synthesis of naturally occurring carbocyclic and heterocyclic-fused pyran compounds, such as (")-dysiherbaine h12CC6295i, penos- tatin B h12OL244i, Greek tobacco lactonic products, and analogues h12TL4293i and on the structurally intriguing limonoids andhraxylocarpins A–E h12CEJ14342i. The stereocontrolled synthesis of fused tetrahydropyrans was used in the preparation of blepharocalyxin D h12AGE3901i. Polyphenolic heterocyclic compounds have also received great attention in 2012. The biological activities and the chemistry of prenylated caged xanthones h12PCB78i, the occurrence of sesquiterpene coumarins h12PR77i, and the medicinal properties of the xanthone mangiferin h12MRME412i have been reviewed. An overview on the asymmetric syntheses of flavanones and chromanones h12EJO449i, on the synthesis and reactivity of flavones h12T8523i and xanthones h12COC2818i, on the synthesis and biosynthesis of biocoumarins h12T2553i, and on the synthesis and applications of flavylium compounds h12CSR869i has been discussed. The most recent developments in the synthesis and applications of sultones, a very important class of sulfur compounds, were reported h12CR5339i. A review on xanthene-based fluorescent probes for sensing cations, anions, bio- logical species, and enzyme activity has described the spiro-ring-opening approach with a focus on the major mechanisms controlling their luminescence behavior h12CR1910i. The design and synthesis of other derivatives to be used as sensors of gold species h12CC11229i and other specific metal cations h12PC823i have also been described. Recent advances related to coumarin-derived fluorescent chemosen- sors for metal ions h12COC2690i and to monitoring in vitro analysis and cellular imaging of monoamine oxidase activity h12CC6833i have been discussed. The study of various organic chromophores allowed the synthesis of novel dica- tionic phloroglucinol-type bisflavylium pigments h12SL2053i, and the optical and spectroscopic properties of several synthetic 6-aryldibenzo[b,d]pyrylium salts were explored h12TL6433i. Discussion of specific reactions leading to O- and S-membered heterocyclic compounds covers intramolecular radical cyclization h12S2475i and asymmetric enamine and dienamine catalysis h12EJO865i, oxa-Michael h12CSR988i and dom- ino Knoevenagel–hetero-Diels–Alder (hDA) reactions h12T5693i, and the versatility in cycloadditions as well as nucleophilic reactions using o-quinones h12CSR1050i. The use of specific reagents relevant to this chapter includes molecular iodine h12CEJ5460, 12COS561i, samarium diiodide–water for selective reductive transfor- mations h12CC330i, o-quinone methides as versatile intermediates h12CEJ9160i, InCl3 as catalyst h12T8683i, and gold and platinum p-acid mediated insertion of alkynes into carbon–heteroatom s-bonds h12S3401i. The remainder of this chapter discusses the most studied transformations on O- and S-6-membered heterocycles

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

GRASPERS - A GRAPHICS DECISION SUPPORT SYSTEM: ITS DEVELOPMENT AND APPLICATIONS

Managers have used graphics for years to support them in their presentations and analysis of information. Conventionally, graphs and charts were prepared by graphic designers and draftsmen. Recently, with the advent of graphics software and appropriate hardware managers can produce their own graphs and charts. Existing computer graphics systems do speed up the graphics drawing process. However, they do not address the most important issue which is graphics selection. Human expertise in graphics design is required to help users select appropriate graphs to accomplish the stated purpose of a graphic presentation. That is, effectiveness is more important than efficiency. Furthermore, existing computer graphics systems are designed as tools for facilitating graphics drawing, not for supporting decision making by graphing. They are intended to be graphics drawing support systems, not graphics decision support systems. An ideal computer graphics system should be both effective and efficient, and easily used by novices. That is, a computer graphics system should contain human expertise in both graphics selecting and drawing processes, and emphasize user friendliness. A graphics decision support system called GRASPERS was designed to achieve the objectives of ease-of-use, efficiency, and effectiveness. The conventional decision support system techniques were used for designing graphics drawing processes. Expert system techniques were used for designing the graphics selecting process. To evaluate the performance of GRASPERS in a real-world situation, a case study was carried out at the Firstier Bank of Lincoln, Nebraska. The results of case study support the contention that GRASPERS has performed as expected

Educational gaps as perceived by IS educators: A survey of knowledge and skill requirements

his paper investigates possible curriculum gaps between required IS skills and achieved IS skills as perceived by IS educators. A survey was conducted to gather their perception about possible curriculum gaps. The authors did find that curriculum gaps exist in eight IS knowledge and skills. Among these eight deficiencies, two are in the interpersonal skill category (interpersonal communication, interpersonal behavior), three are in the personal traits categories (critical thinking, creative thinking, and personal motivation and working independently), and three are in the IS technology category (systems development methodologies, implementation, operation and maintenance issues, and hardware)

Perception gaps between IS academics and IS practitioners: An exploratory study

It has long been recognized that there are significant perception gaps between information systems (IS) academics and IS practitioners with regards to the required IS knowledge/skills to perform their professional jobs successfully. Unfortunately, there is no consensus about which knowledge/skills are more important in the IS profession. With the rapidly changing IS technology and IS industry, a study was urgently needed to find and understand the gaps between these two groups. A study to measure the gap is reported

Information consulting: Developments, trends and suggestions for growth

The article addresses the important developments and trends in the information consulting industry in the 80s and 90s. The rapid evolution and spread of information technology and how it has created a major new set of managerial tasks is analyzed. The birth of several IS consulting firms and how this has changed the way companies look at their businesses is also analyzed. Further, the benefits of information consulting and services provided by the consulting industries are outlined and explained. The big players in the consulting industry and the services provided by them are also addressed. Further, each of the services provided and how these help the various companies in their varied tasks are also evaluated and explained. The article then goes on to address the various trends in consulting and how they provide for a consulting firm\u27s competitive advantage. Finally the article addresses the strategies and steps the consulting firms have adopted in order to prepare themselves for the future. Also, a set of criteria for evaluating and choosing the right consulting company for the right job is outlined for reference